Alpha-amylase 1A

BE0012609ProteinHumansAMY1A

Calcium-binding enzyme that initiates starch digestion in the oral cavity (PubMed:12527308). It is acted on by 3 drugs in DrugBank.

Gene name
AMY1A
UniProtKB entry
P0DUB6Swiss-Prot
Cellular location
Secreted
Residues / weight
511 residues · 57,767 Da
Also known as
1,4-alpha-D-glucan glucanohydrolase 1 · 3.2.1.1 · AMY1 · Salivary alpha-amylase

Resolves to

Protein
UniProtP0DUB6UniProt nameAMY1A_HUMAN
Gene
HGNCHGNC:474NCBI Gene278GeneCardsAMY1A
Pharmacology
KEGGhsa:278
Structure
PDB1C8QPDB1JXJPDB1JXK
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-amylase 1A, how selective are they, and which programs against it are still in active trials?

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