Surfactant protein C

BE0012617ProteinHumansSFTPC

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. It is acted on by 2 drugs in DrugBank.

Gene name
SFTPC
UniProtKB entry
P11686Swiss-Prot
Cellular location
Secreted, extracellular space, surface film
Residues / weight
197 residues · 21,013 Da
Also known as
Pulmonary surfactant-associated protein C · Pulmonary surfactant-associated proteolipid SPL(Val) · SFTP2 · SP-C · SP5

Resolves to

Protein
UniProtP11686UniProt namePSPC_HUMAN
Gene
HGNCHGNC:10802NCBI Gene6440GeneCardsSFTPC
Pharmacology
KEGGhsa:6440
Structure
PDB2YADPDB8OVIPDB8OX2
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Surfactant protein C, how selective are they, and which programs against it are still in active trials?

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