Integrin alpha-2

BE0012664ProteinHumansITGA2

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It is acted on by 2 drugs in DrugBank.

Gene name
ITGA2
UniProtKB entry
P17301Swiss-Prot
Cellular location
Membrane
Residues / weight
1,181 residues · 129,295 Da
Also known as
CD49 antigen-like family member B · CD49B · Collagen receptor · GPIa · Platelet membrane glycoprotein Ia

Resolves to

Protein
UniProtP17301UniProt nameITA2_HUMAN
Gene
HGNCHGNC:6137NCBI Gene3673GeneCardsITGA2
Pharmacology
IUPHAR/GtoPdb2440KEGGhsa:3673
Structure
PDB1AOXPDB1DZIPDB1V7P
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Integrin alpha-2, and which indications are they being tested in?

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