Nucleolar transcription factor 1

BE0012669ProteinHumansUBTF

Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It is acted on by 1 drug in DrugBank.

Gene name
UBTF
UniProtKB entry
P17480Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
764 residues · 89,405 Da
Also known as
Autoantigen NOR-90 · UBF · UBF-1 · UBF1 · Upstream-binding factor 1

Resolves to

Protein
UniProtP17480UniProt nameUBF1_HUMAN
Gene
HGNCHGNC:12511NCBI Gene7343GeneCardsUBTF
Pharmacology
KEGGhsa:7343
Structure
PDB1K99PDB1L8YPDB1L8Z
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Nucleolar transcription factor 1, and which indications are they being tested in?

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