Hepatic triacylglycerol lipase

BE0012718ProteinHumansLIPC

Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA)... It is acted on by 1 drug in DrugBank.

Gene name
LIPC
UniProtKB entry
P11150Swiss-Prot
Cellular location
Secreted
Residues / weight
499 residues · 55,914 Da
Also known as
3.1.1.3 · Hepatic lipase · HL · HTGL · Lipase member C

Resolves to

Protein
UniProtP11150UniProt nameLIPC_HUMAN
Gene
HGNCHGNC:6619NCBI Gene3990GeneCardsLIPC
Pharmacology
KEGGhsa:3990
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Hepatic triacylglycerol lipase, and which indications are they being tested in?

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