Complement receptor type 1

BE0012722ProteinHumansCR1

Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). It is acted on by 1 drug in DrugBank.

Gene name
CR1
UniProtKB entry
P17927Swiss-Prot
Cellular location
Membrane
Residues / weight
2,039 residues · 223,661 Da
Also known as
C3b/C4b receptor · C3BR

Resolves to

Protein
UniProtP17927UniProt nameCR1_HUMAN
Gene
HGNCHGNC:2334NCBI Gene1378GeneCardsCR1
Pharmacology
KEGGhsa:1378
Structure
PDB1GKGPDB1GKNPDB1PPQ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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37GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Complement receptor type 1, and which indications are they being tested in?

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