Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

BE0012731ProteinHumansPPP3CB

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:26794871, PubMed:32753672). It is acted on by 1 drug in DrugBank.

Gene name
PPP3CB
UniProtKB entry
P16298Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
524 residues · 59,024 Da
Also known as
3.1.3.16 · Calmodulin-dependent calcineurin A subunit beta isoform · CALNA2 · CALNB · CAM-PRP catalytic subunit

Resolves to

Protein
UniProtP16298UniProt namePP2BB_HUMAN
Gene
HGNCHGNC:9315NCBI Gene5532GeneCardsPPP3CB
Pharmacology
KEGGhsa:5532
Structure
PDB4OR9PDB4ORAPDB4ORC
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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41GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, and which indications are they being tested in?

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