Nucleolin
Details
- Name
- Nucleolin
- Kind
- protein
- Synonyms
- Protein C23
- Gene Name
- NCL
- UniProtKB Entry
- P19338Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0055993|Nucleolin MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATS AKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVA TPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAA APASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEE DDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEG TEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDL EKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIR LVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNST WSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEAL NSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARI VTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGR GGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
- Number of residues
- 710
- Molecular Weight
- 76613.855
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA topoisomerase binding / identical protein binding / insulin receptor substrate binding / mRNA 5'-UTR binding / PH domain binding / RNA binding / telomeric DNA bindingProcessesangiogenesis / cellular response to epidermal growth factor stimulus / cellular response to leukemia inhibitory factor / negative regulation of insulin receptor signaling pathway / negative regulation of translation / positive regulation of mRNA splicing, via spliceosome / positive regulation of transcription by RNA polymerase II / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / regulation of peptidyl-tyrosine phosphorylationComponentscell cortex / chromosome / cornified envelope / cytoplasmic ribonucleoprotein granule / extracellular exosome / macropinosome membrane / membrane / nucleolus / nucleoplasm / nucleus / plasma membrane / ribonucleoprotein complex / spliceosomal complex
- General Function
- Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats
- Specific Function
- DNA topoisomerase binding
- Pfam Domain Function
- RRM_1 (PF00076)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus, nucleolus
- Gene sequence
- Not Available
- Chromosome Location
- 2
- Locus
- 2q37.1
- External Identifiers
Resource Link UniProtKB ID P19338 UniProtKB Entry Name NUCL_HUMAN GeneCard ID NCL HGNC ID HGNC:7667 PDB ID(s) 2FC8, 2FC9, 2KRR KEGG ID hsa:4691 NCBI Gene ID 4691 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Quarfloxin investigational yes target inhibitor Details