General transcription and DNA repair factor IIH helicase/translocase subunit XPB

BE0012820ProteinHumansERCC3

ATP-dependent 3'-5' DNA helicase/translocase (PubMed:17466626, PubMed:27193682, PubMed:33902107, PubMed:8465201, PubMed:8663148). It is acted on by 1 drug in DrugBank.

Gene name
ERCC3
UniProtKB entry
P19447Swiss-Prot
Cellular location
Nucleus
Residues / weight
782 residues · 89,277 Da
Also known as
5.6.2.4 · Basic transcription factor 2 89 kDa subunit · BTF2 p89 · DNA 3'-5' helicase/translocase XPB · DNA excision repair protein ERCC-3

Resolves to

Protein
UniProtP19447UniProt nameERCC3_HUMAN
Gene
HGNCHGNC:3435NCBI Gene2071GeneCardsERCC3
Pharmacology
KEGGhsa:2071
Structure
PDB28JMPDB28JSPDB28JV
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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28GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on General transcription and DNA repair factor IIH helicase/translocase subunit XPB, how selective are they, and which programs against it are still in active trials?

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