Transcription factor EB

BE0012824ProteinHumansTFEB

Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943, PubMed:22576015, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32612235, PubMed:32753672, PubMed:35662396, PubMed:36697823, PubMed:36749723, PubMed:37079666). It is acted on by 2 drugs in DrugBank.

Gene name
TFEB
UniProtKB entry
P19484Swiss-Prot
Cellular location
Nucleus
Residues / weight
476 residues · 52,864 Da
Also known as
BHLHE35 · Class E basic helix-loop-helix protein 35

Resolves to

Protein
UniProtP19484UniProt nameTFEB_HUMAN
Gene
HGNCHGNC:11753NCBI Gene7942GeneCardsTFEB
Pharmacology
KEGGhsa:7942
Structure
PDB7UX2PDB7UXCPDB7UXH
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Transcription factor EB, and which indications are they being tested in?

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