Ceramide synthase 1

BE0012836ProteinHumansCERS1

Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). It is acted on by 1 drug in DrugBank.

Gene name
CERS1
UniProtKB entry
P27544Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
350 residues · 39,536 Da
Also known as
CerS1 · LAG1 · LAG1 longevity assurance homolog 1 · LASS1 · Longevity assurance gene 1 protein homolog 1

Resolves to

Protein
UniProtP27544UniProt nameCERS1_HUMAN
Gene
HGNCHGNC:14253NCBI Gene10715GeneCardsCERS1
Pharmacology
KEGGhsa:10715
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
14GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Ceramide synthase 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In