N-formyl peptide receptor 2

BE0012843ProteinHumansFPR2

Pattern recognition G protein-coupled receptor (GPCR) that recognizes peptides with N-terminal formyl methionine, which are derived from invading pathogens or host mitochondria as pathogen or damage-associated molecular patterns (PAMPs and DAMPs) (PubMed:1374236, PubMed:25605714, PubMed:35217703). It is acted on by 2 drugs in DrugBank.

Gene name
FPR2
UniProtKB entry
P25090Swiss-Prot
Cellular location
Cell membrane
Residues / weight
351 residues · 38,964 Da
Also known as
ALX · FMLP-R-I · FMLP-related receptor I · Formyl peptide receptor-like 1 · FPRH1

Resolves to

Protein
UniProtP25090UniProt nameFPR2_HUMAN
Gene
HGNCHGNC:3827NCBI Gene2358GeneCardsFPR2
Pharmacology
IUPHAR/GtoPdb223KEGGhsa:2358
Structure
PDB6LW5PDB6OMMPDB7T6S
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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37GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on N-formyl peptide receptor 2, and which indications are they being tested in?

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