TATA-box-binding protein

BE0012882ProteinHumansTBP

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). It is acted on by 1 drug in DrugBank.

Gene name
TBP
UniProtKB entry
P20226Swiss-Prot
Cellular location
Nucleus
Residues / weight
339 residues · 37,698 Da
Also known as
GTF2D1 · TATA sequence-binding protein · TATA-binding factor · TATA-box factor · TF2D

Resolves to

Protein
UniProtP20226UniProt nameTBP_HUMAN
Gene
HGNCHGNC:11588NCBI Gene6908GeneCardsTBP
Pharmacology
KEGGhsa:6908
Structure
PDB1C9BPDB1CDWPDB1JFI
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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32GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on TATA-box-binding protein, and which indications are they being tested in?

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