Myristoylated alanine-rich C-kinase substrate

BE0012891ProteinHumansMARCKS

Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). It is acted on by 1 drug in DrugBank.

Gene name
MARCKS
UniProtKB entry
P29966Swiss-Prot
Cellular location
Cell membrane
Residues / weight
332 residues · 31,554 Da
Also known as
80K-L protein · MACS · MARCKS · PKCSL · PRKCSL

Resolves to

Protein
UniProtP29966UniProt nameMARCS_HUMAN
Gene
HGNCHGNC:6759NCBI Gene4082GeneCardsMARCKS
Pharmacology
KEGGhsa:4082
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Myristoylated alanine-rich C-kinase substrate, and which indications are they being tested in?

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