Lactoperoxidase

BE0012922ProteinHumansLPO

Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (PubMed:6295491). It is acted on by 5 drugs in DrugBank.

Gene name
LPO
UniProtKB entry
P22079Swiss-Prot
Cellular location
Secreted
Residues / weight
712 residues · 80,287 Da
Also known as
1.11.1.7 · LPO · Salivary peroxidase · SAPX · SPO

Resolves to

Protein
UniProtP22079UniProt namePERL_HUMAN
Gene
HGNCHGNC:6678NCBI Gene4025GeneCardsLPO
Pharmacology
KEGGhsa:4025
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lactoperoxidase, how selective are they, and which programs against it are still in active trials?

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