Ciliary neurotrophic factor receptor subunit alpha

BE0012974ProteinHumansCNTFR

Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1... It is acted on by 1 drug in DrugBank.

Gene name
CNTFR
UniProtKB entry
P26992Swiss-Prot
Cellular location
Cell membrane
Residues / weight
372 residues · 40,633 Da
Also known as
CNTF receptor subunit alpha · CNTFR-alpha

Resolves to

Protein
UniProtP26992UniProt nameCNTFR_HUMAN
Gene
HGNCHGNC:2170NCBI Gene1271GeneCardsCNTFR
Pharmacology
KEGGhsa:1271
Structure
PDB1UC6PDB8D74PDB8D7E
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ciliary neurotrophic factor receptor subunit alpha, how selective are they, and which programs against it are still in active trials?

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