Glucose-6-phosphatase catalytic subunit 1

BE0013006ProteinHumansG6PC1

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. It is acted on by 1 drug in DrugBank.

Gene name: G6PC1
UniProtKB entry: P35575Swiss-Prot
Cellular location: Endoplasmic reticulum membrane
Residues / weight: 357 residues · 40,483 Da
Also known as: 3.1.3.9 · G-6-Pase · G6Pase · G6Pase-alpha · G6PC

Resolves to

Protein

UniProtP35575UniProt nameG6PC1_HUMAN

Gene

HGNCHGNC:4056NCBI Gene2538GeneCardsG6PC1

Pharmacology

KEGGhsa:2538

Structure

PDB9J7UPDB9J7VPDB9JTL

Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action

10GO termsFunction, process and component, as structured annotations

1Pfam domainDomain architecture mapped to Pfam families and clans

1+ReferenceStructured and connected to the statements they support

Which approved drugs act on Glucose-6-phosphatase catalytic subunit 1, how selective are they, and which programs against it are still in active trials?

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