DNA-binding protein SMUBP-2

BE0013009ProteinHumansIGHMBP2

5' to 3' helicase that unwinds both RNA and DNA duplexes in an ATP-dependent reaction (Probable) (PubMed:19158098, PubMed:30218034). It is acted on by 1 drug in DrugBank.

Gene name
IGHMBP2
UniProtKB entry
P38935Swiss-Prot
Cellular location
Nucleus
Residues / weight
993 residues · 109,148 Da
Also known as
5.6.2.3 · 5.6.2.5 · ATP-dependent helicase IGHMBP2 · DNA and RNA 5'-3' helicase IGHMBP2 · GF-1

Resolves to

Protein
UniProtP38935UniProt nameSMBP2_HUMAN
Gene
HGNCHGNC:5542NCBI Gene3508GeneCardsIGHMBP2
Pharmacology
KEGGhsa:3508
Structure
PDB1MSZPDB2LRRPDB4B3F
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on DNA-binding protein SMUBP-2, and which indications are they being tested in?

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