DNA polymerase delta catalytic subunit

BE0013106ProteinHumansPOLD1

As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:16510448, PubMed:19074196,... It is acted on by 1 drug in DrugBank.

Gene name
POLD1
UniProtKB entry
P28340Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,107 residues · 123,630 Da
Also known as
2.7.7.7 · 3'-5' exodeoxyribonuclease · DNA polymerase subunit delta p125 · POLD

Resolves to

Protein
UniProtP28340UniProt nameDPOD1_HUMAN
Gene
HGNCHGNC:9175NCBI Gene5424GeneCardsPOLD1
Pharmacology
KEGGhsa:5424
Structure
PDB6S1MPDB6S1NPDB6S1O
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase delta catalytic subunit, how selective are they, and which programs against it are still in active trials?

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