Dual specificity protein phosphatase 1

Details

Name
Dual specificity protein phosphatase 1
Kind
protein
Synonyms
  • 3.1.3.16
  • 3.1.3.48
  • CL100
  • Dual specificity protein phosphatase hVH1
  • MAP kinase phosphatase 1
  • Mitogen-activated protein kinase phosphatase 1
  • MKP-1
  • MKP1
  • Protein-tyrosine phosphatase CL100
  • PTPN10
  • VH1
Gene Name
DUSP1
UniProtKB Entry
P28562Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0013919|Dual specificity protein phosphatase 1
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM
GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF
LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF
LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA
IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS
FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP
ITTSPSC
Number of residues
367
Molecular Weight
39297.37
Theoretical pI
Not Available
GO Classification
Functions
MAP kinase tyrosine phosphatase activity / MAP kinase tyrosine/serine/threonine phosphatase activity / mitogen-activated protein kinase binding / myosin phosphatase activity / protein serine/threonine phosphatase activity / protein tyrosine phosphatase activity / protein tyrosine/serine/threonine phosphatase activity / protein tyrosine/threonine phosphatase activity
Processes
cellular response to chemokine / endoderm formation / negative regulation of cell adhesion / negative regulation of cell population proliferation / negative regulation of MAP kinase activity / negative regulation of MAPK cascade / negative regulation of meiotic cell cycle / negative regulation of monocyte chemotaxis / negative regulation of p38MAPK cascade / peptidyl-serine dephosphorylation / peptidyl-threonine dephosphorylation / peptidyl-tyrosine dephosphorylation / regulation of mitotic cell cycle spindle assembly checkpoint
Components
cytoplasm / nucleus
General Function
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle
Specific Function
MAP kinase tyrosine phosphatase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
Not Available
Chromosome Location
5
Locus
5q35.1
External Identifiers
ResourceLink
UniProtKB IDP28562
UniProtKB Entry NameDUS1_HUMAN
GeneCard IDDUSP1
HGNC IDHGNC:3064
PDB ID(s)6APX, 6D65, 6D66, 6D67
KEGG IDhsa:1843
NCBI Gene ID1843
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
9,10-Deepithio-9,10-DidehydroacanthifolicinexperimentalyestargetinhibitorDetails