Dual specificity protein phosphatase 1
Details
- Name
- Dual specificity protein phosphatase 1
- Kind
- protein
- Synonyms
- 3.1.3.16
- 3.1.3.48
- CL100
- Dual specificity protein phosphatase hVH1
- MAP kinase phosphatase 1
- Mitogen-activated protein kinase phosphatase 1
- MKP-1
- MKP1
- Protein-tyrosine phosphatase CL100
- PTPN10
- VH1
- Gene Name
- DUSP1
- UniProtKB Entry
- P28562Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0013919|Dual specificity protein phosphatase 1 MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP ITTSPSC
- Number of residues
- 367
- Molecular Weight
- 39297.37
- Theoretical pI
- Not Available
- GO Classification
- FunctionsMAP kinase tyrosine phosphatase activity / MAP kinase tyrosine/serine/threonine phosphatase activity / mitogen-activated protein kinase binding / myosin phosphatase activity / protein serine/threonine phosphatase activity / protein tyrosine phosphatase activity / protein tyrosine/serine/threonine phosphatase activity / protein tyrosine/threonine phosphatase activityProcessescellular response to chemokine / endoderm formation / negative regulation of cell adhesion / negative regulation of cell population proliferation / negative regulation of MAP kinase activity / negative regulation of MAPK cascade / negative regulation of meiotic cell cycle / negative regulation of monocyte chemotaxis / negative regulation of p38MAPK cascade / peptidyl-serine dephosphorylation / peptidyl-threonine dephosphorylation / peptidyl-tyrosine dephosphorylation / regulation of mitotic cell cycle spindle assembly checkpointComponentscytoplasm / nucleus
- General Function
- Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle
- Specific Function
- MAP kinase tyrosine phosphatase activity
- Pfam Domain Function
- Rhodanese (PF00581)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
- Not Available
- Chromosome Location
- 5
- Locus
- 5q35.1
- External Identifiers
Resource Link UniProtKB ID P28562 UniProtKB Entry Name DUS1_HUMAN GeneCard ID DUSP1 HGNC ID HGNC:3064 PDB ID(s) 6APX, 6D65, 6D66, 6D67 KEGG ID hsa:1843 NCBI Gene ID 1843 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 9,10-Deepithio-9,10-Didehydroacanthifolicin experimental yes target inhibitor Details