Dual specificity protein phosphatase 1

BE0013126ProteinHumansDUSP1

Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. It is acted on by 1 drug in DrugBank.

Gene name
DUSP1
UniProtKB entry
P28562Swiss-Prot
Cellular location
Nucleus
Residues / weight
367 residues · 39,297 Da
Also known as
3.1.3.16 · 3.1.3.48 · CL100 · Dual specificity protein phosphatase hVH1 · MAP kinase phosphatase 1

Resolves to

Protein
UniProtP28562UniProt nameDUS1_HUMAN
Gene
HGNCHGNC:3064NCBI Gene1843GeneCardsDUSP1
Pharmacology
KEGGhsa:1843
Structure
PDB6APXPDB6D65PDB6D66
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Dual specificity protein phosphatase 1, and which indications are they being tested in?

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