Beta-arrestin-2

BE0013128ProteinHumansARRB2

Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:16179383, PubMed:37209686, PubMed:38175886, PubMed:40384633). It is acted on by 1 drug in DrugBank.

Gene name
ARRB2
UniProtKB entry
P32121Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
409 residues · 46,105 Da
Also known as
ARB2 · ARR2 · Arrestin beta-2 · Non-visual arrestin-3

Resolves to

Protein
UniProtP32121UniProt nameARRB2_HUMAN
Gene
HGNCHGNC:712NCBI Gene409GeneCardsARRB2
Pharmacology
KEGGhsa:409
Structure
PDB9UYM
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Beta-arrestin-2, how selective are they, and which programs against it are still in active trials?

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