Caspase-2

BE0013189ProteinHumansCASP2

Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). It is acted on by 1 drug in DrugBank.

Gene name
CASP2
UniProtKB entry
P42575Swiss-Prot
Residues / weight
452 residues · 50,685 Da
Also known as
3.4.22.55 · CASP-2 · ICH1 · NEDD-2 · NEDD2

Resolves to

Protein
UniProtP42575UniProt nameCASP2_HUMAN
Gene
HGNCHGNC:1503NCBI Gene835GeneCardsCASP2
Pharmacology
IUPHAR/GtoPdb1618KEGGhsa:835
Structure
PDB1PYOPDB2P2CPDB3R5J
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Caspase-2, and which indications are they being tested in?

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