Leukemia inhibitory factor receptor

BE0013220ProteinHumansLIFR

Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR (PubMed:11285233, PubMed:11294841, PubMed:1542794, PubMed:39532904, PubMed:9030543, PubMed:9188471). It is acted on by 1 drug in DrugBank.

Gene name
LIFR
UniProtKB entry
P42702Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,097 residues · 123,742 Da
Also known as
LIF receptor · LIF-R

Resolves to

Protein
UniProtP42702UniProt nameLIFR_HUMAN
Gene
HGNCHGNC:6597NCBI Gene3977GeneCardsLIFR
Pharmacology
KEGGhsa:3977
Structure
PDB3E0GPDB8D6APDB8D74
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Leukemia inhibitory factor receptor, and which indications are they being tested in?

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