Acyl-coenzyme A thioesterase 2, mitochondrial

BE0013225ProteinHumansACOT2

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). It is acted on by 1 drug in DrugBank.

Gene name
ACOT2
UniProtKB entry
P49753Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
483 residues · 53,218 Da
Also known as
3.1.2.2 · Acyl-CoA thioesterase 2 · Acyl-coenzyme A thioester hydrolase 2a · CTE-Ia · Long-chain acyl-CoA thioesterase 2

Resolves to

Protein
UniProtP49753UniProt nameACOT2_HUMAN
Gene
HGNCHGNC:18431NCBI Gene10965GeneCardsACOT2
Pharmacology
KEGGhsa:10965
Structure
PDB3HLK
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Acyl-coenzyme A thioesterase 2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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