SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

BE0013298ProteinHumansSMARCA2

ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). It is acted on by 1 drug in DrugBank.

Gene name: SMARCA2
UniProtKB entry: P51531Swiss-Prot
Cellular location: Nucleus
Residues / weight: 1,590 residues · 181,278 Da
Also known as: 3.6.4.- · BAF190B · BRG1-associated factor 190B · BRM · hBRM

Resolves to

Protein

UniProtP51531UniProt nameSMCA2_HUMAN

Gene

HGNCHGNC:11098NCBI Gene6595GeneCardsSMARCA2

Pharmacology

IUPHAR/GtoPdb2739KEGGhsa:6595

Structure

PDB2DATPDB4QY4PDB5DKC

Drugs

What you can answer from here — as of June 26, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action

7Pfam domainsDomain architecture mapped to Pfam families and clans

3+ReferencesStructured and connected to the statements they support

Which compounds in development act on SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2, and which indications are they being tested in?

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