Natural resistance-associated macrophage protein 1

BE0013320ProteinHumansSLC11A1

Antiporter that transports metal ions against a proton gradient, and which promotes host resistance to infection against intracellular parasites, such as M.bovis, S.typhimurium and L.donovani (PubMed:11237855, PubMed:16103355, PubMed:16395392, PubMed:39824808). It is acted on by 1 drug in DrugBank.

Gene name
SLC11A1
UniProtKB entry
P49279Swiss-Prot
Cellular location
Cytoplasmic vesicle, phagosome membrane
Residues / weight
550 residues · 59,872 Da
Also known as
LSH · NRAMP · NRAMP 1 · NRAMP1 · Solute carrier family 11 member 1

Resolves to

Protein
UniProtP49279UniProt nameNRAM1_HUMAN
Gene
HGNCHGNC:10907NCBI Gene6556GeneCardsSLC11A1
Pharmacology
KEGGhsa:6556
Structure
PDB9F6PPDB9F6Q
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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51GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Natural resistance-associated macrophage protein 1, and which indications are they being tested in?

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