Beta-arrestin-1

BE0013340ProteinHumansARRB1

Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:37209686, PubMed:38175886, PubMed:40384633). It is acted on by 1 drug in DrugBank.

Gene name
ARRB1
UniProtKB entry
P49407Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
418 residues · 47,065 Da
Also known as
ARR1 · Arrestin beta-1 · Non-visual arrestin-2

Resolves to

Protein
UniProtP49407UniProt nameARRB1_HUMAN
Gene
HGNCHGNC:711NCBI Gene408GeneCardsARRB1
Pharmacology
KEGGhsa:408
Structure
PDB2IV8PDB6PWCPDB6TKO
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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51GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Beta-arrestin-1, how selective are they, and which programs against it are still in active trials?

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