Protoporphyrinogen oxidase

BE0013344ProteinHumansPPOX

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. It is acted on by 2 drugs in DrugBank.

Gene name
PPOX
UniProtKB entry
P50336Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
477 residues · 50,765 Da
Also known as
1.3.3.4 · PPO

Resolves to

Protein
UniProtP50336UniProt namePPOX_HUMAN
Gene
HGNCHGNC:9280NCBI Gene5498GeneCardsPPOX
Pharmacology
KEGGhsa:5498
Structure
PDB3NKSPDB4IVMPDB4IVO
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
10GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Protoporphyrinogen oxidase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In