Dynamin-2

BE0013402ProteinHumansDNM2

Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620,... It is acted on by 2 drugs in DrugBank.

Gene name
DNM2
UniProtKB entry
P50570Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton
Residues / weight
870 residues · 98,063 Da
Also known as
3.6.5.5 · DYN2 · Dynamin 2 · Dynamin II

Resolves to

Protein
UniProtP50570UniProt nameDYN2_HUMAN
Gene
HGNCHGNC:2974NCBI Gene1785GeneCardsDNM2
Pharmacology
KEGGhsa:1785
Structure
PDB2YS1
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dynamin-2, and which indications are they being tested in?

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