RecQ-like DNA helicase BLM

BE0013493ProteinHumansBLM

ATP-dependent DNA helicase that unwinds double-stranded (ds)DNA in a 3'-5' direction (PubMed:24816114, PubMed:25901030, PubMed:9388193, PubMed:9765292). It is acted on by 1 drug in DrugBank.

Gene name
BLM
UniProtKB entry
P54132Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,417 residues · 158,999 Da
Also known as
5.6.2.4 · Bloom syndrome protein · DNA 3'-5' helicase BLM · DNA helicase, RecQ-like type 2 · RecQ protein-like 3

Resolves to

Protein
UniProtP54132UniProt nameBLM_HUMAN
Gene
HGNCHGNC:1058NCBI Gene641GeneCardsBLM
Pharmacology
IUPHAR/GtoPdb3260KEGGhsa:641
Structure
PDB2KV2PDB2MH9PDB2RRD
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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57GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on RecQ-like DNA helicase BLM, and which indications are they being tested in?

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