Ataxin-3

BE0013512ProteinHumansATXN3

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:16118278, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:33157014). It is acted on by 1 drug in DrugBank.

Gene name
ATXN3
UniProtKB entry
P54252Swiss-Prot
Cellular location
Nucleus matrix
Residues / weight
361 residues · 41,250 Da
Also known as
3.4.19.12 · ATX3 · Machado-Joseph disease protein 1 · MJD · MJD1

Resolves to

Protein
UniProtP54252UniProt nameATX3_HUMAN
Gene
HGNCHGNC:7106NCBI Gene4287GeneCardsATXN3
Pharmacology
KEGGhsa:4287
Structure
PDB1YZBPDB2AGAPDB2DOS
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Ataxin-3, and which indications are they being tested in?

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