Ataxin-1

BE0013516ProteinHumansATXN1

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. It is acted on by 1 drug in DrugBank.

Gene name
ATXN1
UniProtKB entry
P54253Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
815 residues · 86,922 Da
Also known as
ATX1 · SCA1 · Spinocerebellar ataxia type 1 protein

Resolves to

Protein
UniProtP54253UniProt nameATX1_HUMAN
Gene
HGNCHGNC:10548NCBI Gene6310GeneCardsATXN1
Pharmacology
KEGGhsa:6310
Structure
PDB1OA8PDB2M41PDB4APT
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Ataxin-1, and which indications are they being tested in?

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