Dicarboxylate carrier SLC25A8

BE0013557ProteinHumansUCP2

Antiporter that exports dicarboxylate intermediates of the Krebs cycle in exchange for phosphate plus a proton across the inner membrane of mitochondria, a process driven by mitochondrial motive force with an overall impact on glycolysis,... It is acted on by 1 drug in DrugBank.

Gene name
UCP2
UniProtKB entry
P55851Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
309 residues · 33,229 Da
Also known as
Mitochondrial uncoupling protein 2 · SLC25A8 · Solute carrier family 25 member 8 · UCP 2 · UCPH

Resolves to

Protein
UniProtP55851UniProt nameUCP2_HUMAN
Gene
HGNCHGNC:12518NCBI Gene7351GeneCardsUCP2
Pharmacology
KEGGhsa:7351
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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37GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Dicarboxylate carrier SLC25A8, and which indications are they being tested in?

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