GDNF family receptor alpha-1

BE0013583ProteinHumansGFRA1

Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:10829012, PubMed:31535977). It is acted on by 1 drug in DrugBank.

Gene name
GFRA1
UniProtKB entry
P56159Swiss-Prot
Cellular location
Cell membrane
Residues / weight
465 residues · 51,455 Da
Also known as
GDNF receptor alpha-1 · GDNFR-alpha-1 · GDNFRA · GFR-alpha-1 · RET ligand 1

Resolves to

Protein
UniProtP56159UniProt nameGFRA1_HUMAN
Gene
HGNCHGNC:4243NCBI Gene2674GeneCardsGFRA1
Pharmacology
IUPHAR/GtoPdb1743KEGGhsa:2674
Structure
PDB6Q2N
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on GDNF family receptor alpha-1, and which indications are they being tested in?

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