Retinal guanylyl cyclase 1

BE0013774ProteinHumansGUCY2D

Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. It is acted on by 2 drugs in DrugBank.

Gene name
GUCY2D
UniProtKB entry
Q02846Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
1,103 residues · 120,057 Da
Also known as
4.6.1.2 · CG-E · CORD6 · Guanylate cyclase 2D, retinal · GUC1A4

Resolves to

Protein
UniProtQ02846UniProt nameGUC2D_HUMAN
Gene
HGNCHGNC:4689NCBI Gene3000GeneCardsGUCY2D
Pharmacology
KEGGhsa:3000
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinal guanylyl cyclase 1, how selective are they, and which programs against it are still in active trials?

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