Retinal-specific phospholipid-transporting ATPase ABCA4

BE0013860ProteinHumansABCA4

Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine (N-Ret-PE) from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where 11-cis-retinylidene-phosphatidylethanolamine... It is acted on by 1 drug in DrugBank.

Gene name
ABCA4
UniProtKB entry
P78363Swiss-Prot
Cellular location
Membrane
Residues / weight
2,273 residues · 255,941 Da
Also known as
7.6.2.1 · ABCR · ATP-binding cassette sub-family A member 4 · Retinal-specific ATP-binding cassette transporter · RIM ABC transporter

Resolves to

Protein
UniProtP78363UniProt nameABCA4_HUMAN
Gene
HGNCHGNC:34NCBI Gene24GeneCardsABCA4
Pharmacology
KEGGhsa:24
Structure
PDB7E7IPDB7E7OPDB7E7Q
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Retinal-specific phospholipid-transporting ATPase ABCA4, and which indications are they being tested in?

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