Endonuclease III-like protein 1

BE0013972ProteinHumansNTHL1

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:29610152, PubMed:9927729). It is acted on by 1 drug in DrugBank.

Gene name
NTHL1
UniProtKB entry
P78549Swiss-Prot
Cellular location
Nucleus
Residues / weight
304 residues · 33,569 Da
Also known as
3.2.2.- · 4.2.99.18 · Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase · DNA glycosylase/AP lyase · hNTH1

Resolves to

Protein
UniProtP78549UniProt nameNTH_HUMAN
Gene
HGNCHGNC:8028NCBI Gene4913GeneCardsNTHL1
Pharmacology
KEGGhsa:4913
Structure
PDB7RDSPDB7RDT
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Endonuclease III-like protein 1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In