Endonuclease III-like protein 1

BE0013972ProteinHumansNTHL1

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:29610152, PubMed:9927729). It is acted on by 1 drug in DrugBank.

Gene name
NTHL1
UniProtKB entry
P78549Swiss-Prot
Cellular location
Nucleus
Residues / weight
304 residues · 33,569 Da
Also known as
3.2.2.- · 4.2.99.18 · Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase · DNA glycosylase/AP lyase · hNTH1

Resolves to

Protein
UniProtP78549UniProt nameNTH_HUMAN
Gene
HGNCHGNC:8028NCBI Gene4913GeneCardsNTHL1
Pharmacology
KEGGhsa:4913
Structure
PDB7RDSPDB7RDT
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Endonuclease III-like protein 1, and which indications are they being tested in?

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