Dynamin-1

BE0013996ProteinHumansDNM1

Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:15703209,... It is acted on by 1 drug in DrugBank.

Gene name
DNM1
UniProtKB entry
Q05193Swiss-Prot
Cellular location
Cell membrane
Residues / weight
864 residues · 97,407 Da
Also known as
3.6.5.5 · DNM · Dynamin · Dynamin I

Resolves to

Protein
UniProtQ05193UniProt nameDYN1_HUMAN
Gene
HGNCHGNC:2972NCBI Gene1759GeneCardsDNM1
Pharmacology
KEGGhsa:1759
Structure
PDB1DYNPDB2DYNPDB2X2E
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Dynamin-1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In