Recombining binding protein suppressor of hairless

BE0014074ProteinHumansRBPJ

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:41086914, PubMed:36129980). It is acted on by 1 drug in DrugBank.

Gene name
RBPJ
UniProtKB entry
Q06330Swiss-Prot
Cellular location
Nucleus
Residues / weight
500 residues · 55,637 Da
Also known as
CBF-1 · IGKJRB · IGKJRB1 · J kappa-recombination signal-binding protein · RBP-J

Resolves to

Protein
UniProtQ06330UniProt nameSUH_HUMAN
Gene
HGNCHGNC:5724NCBI Gene3516GeneCardsRBPJ
Pharmacology
KEGGhsa:3516
Structure
PDB2F8XPDB3NBNPDB3V79
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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52GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Recombining binding protein suppressor of hairless, and which indications are they being tested in?

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