Interleukin-18 receptor 1

BE0014121ProteinHumansIL18R1

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725). It is acted on by 1 drug in DrugBank.

Gene name
IL18R1
UniProtKB entry
Q13478Swiss-Prot
Cellular location
Membrane
Residues / weight
541 residues · 62,303 Da
Also known as
3.2.2.6 · CD218 antigen-like family member A · CDw218a · IL-18R-1 · IL-18R-alpha

Resolves to

Protein
UniProtQ13478UniProt nameIL18R_HUMAN
Gene
HGNCHGNC:5988NCBI Gene8809GeneCardsIL18R1
Pharmacology
KEGGhsa:8809
Structure
PDB3WO3PDB3WO4PDB4R6U
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Interleukin-18 receptor 1, and which indications are they being tested in?

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