Sequestosome-1

BE0014160ProteinHumansSQSTM1

Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:22017874, PubMed:22622177, PubMed:24128730, PubMed:28404643, PubMed:29343546, PubMed:29507397, PubMed:31857589, PubMed:33509017, PubMed:34471133, PubMed:34893540, PubMed:35831301, PubMed:37306101, PubMed:37802024,... It is acted on by 1 drug in DrugBank.

Gene name
SQSTM1
UniProtKB entry
Q13501Swiss-Prot
Cellular location
Cytoplasmic vesicle, autophagosome
Residues / weight
440 residues · 47,687 Da
Also known as
EBI3-associated protein of 60 kDa · EBIAP · ORCA · OSIL · p60

Resolves to

Protein
UniProtQ13501UniProt nameSQSTM_HUMAN
Gene
HGNCHGNC:11280NCBI Gene8878GeneCardsSQSTM1
Pharmacology
IUPHAR/GtoPdb3213KEGGhsa:8878
Structure
PDB1Q02PDB2JY7PDB2JY8
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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73GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Sequestosome-1, and which indications are they being tested in?

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