Interleukin-10 receptor subunit beta

BE0014312ProteinHumansIL10RB

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. It is acted on by 3 drugs in DrugBank.

Gene name
IL10RB
UniProtKB entry
Q08334Swiss-Prot
Cellular location
Membrane
Residues / weight
325 residues · 36,995 Da
Also known as
CRF2-4 · CRFB4 · Cytokine receptor class-II member 4 · Cytokine receptor family 2 member 4 · D21S58

Resolves to

Protein
UniProtQ08334UniProt nameI10R2_HUMAN
Gene
HGNCHGNC:5965NCBI Gene3588GeneCardsIL10RB
Pharmacology
IUPHAR/GtoPdb1728KEGGhsa:3588
Structure
PDB3LQMPDB5T5WPDB6X93
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Interleukin-10 receptor subunit beta, and which indications are they being tested in?

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