Translation initiation factor eIF2B subunit epsilon

BE0014384ProteinHumansEIF2B5

Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). It is acted on by 1 drug in DrugBank.

Gene name
EIF2B5
UniProtKB entry
Q13144Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
721 residues · 80,379 Da
Also known as
eIF2B GDP-GTP exchange factor subunit epsilon · EIF2BE

Resolves to

Protein
UniProtQ13144UniProt nameEI2BE_HUMAN
Gene
HGNCHGNC:3261NCBI Gene8893GeneCardsEIF2B5
Pharmacology
KEGGhsa:8893
Structure
PDB3JUIPDB6CAJPDB6EZO
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Translation initiation factor eIF2B subunit epsilon, and which indications are they being tested in?

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