Nuclear receptor coactivator 4

BE0014405ProteinHumansNCOA4

Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). It is acted on by 1 drug in DrugBank.

Gene name
NCOA4
UniProtKB entry
Q13772Swiss-Prot
Cellular location
Cytoplasmic vesicle, autophagosome
Residues / weight
614 residues · 69,726 Da
Also known as
70 kDa androgen receptor coactivator · 70 kDa AR-activator · Androgen receptor coactivator 70 kDa protein · Androgen receptor-associated protein of 70 kDa · ARA70

Resolves to

Protein
UniProtQ13772UniProt nameNCOA4_HUMAN
Gene
HGNCHGNC:7671NCBI Gene8031GeneCardsNCOA4
Pharmacology
KEGGhsa:8031
Structure
PDB1T5ZPDB8QU9PDB9L93
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Nuclear receptor coactivator 4, and which indications are they being tested in?

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