Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

BE0014411ProteinHumansWRN

Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates (PubMed:9224595, PubMed:9288107, PubMed:9611231). It is acted on by 1 drug in DrugBank.

Gene name
WRN
UniProtKB entry
Q14191Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
1,432 residues · 162,459 Da
Also known as
DNA helicase, RecQ-like type 3 · RecQ protein-like 2 · RECQ3 · RECQL2 · Werner syndrome protein

Resolves to

Protein
UniProtQ14191UniProt nameWRN_HUMAN
Gene
HGNCHGNC:12791NCBI Gene7486GeneCardsWRN
Pharmacology
IUPHAR/GtoPdb3259KEGGhsa:7486
Structure
PDB2AXLPDB2DGZPDB2E1E
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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49GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, and which indications are they being tested in?

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