Mannosyl-oligosaccharide glucosidase

BE0014425ProteinHumansMOGS

In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner. It is acted on by 1 drug in DrugBank.

Gene name
MOGS
UniProtKB entry
Q13724Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
837 residues · 91,917 Da
Also known as
3.2.1.106 · GCS1 · Processing A-glucosidase I

Resolves to

Protein
UniProtQ13724UniProt nameMOGS_HUMAN
Gene
HGNCHGNC:24862NCBI Gene7841GeneCardsMOGS
Pharmacology
KEGGhsa:7841
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mannosyl-oligosaccharide glucosidase, and which indications are they being tested in?

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