Transforming growth factor beta activator LRRC32

BE0014554ProteinHumansLRRC32

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). It is acted on by 1 drug in DrugBank.

Gene name
LRRC32
UniProtKB entry
Q14392Swiss-Prot
Cellular location
Cell membrane
Residues / weight
662 residues · 71,978 Da
Also known as
D11S833E · GARP · Garpin · Glycoprotein A repetitions predominant · Leucine-rich repeat-containing protein 32

Resolves to

Protein
UniProtQ14392UniProt nameLRC32_HUMAN
Gene
HGNCHGNC:4161NCBI Gene2615GeneCardsLRRC32
Pharmacology
IUPHAR/GtoPdb2913KEGGhsa:2615
Structure
PDB6GFFPDB8C7HPDB8REW
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Transforming growth factor beta activator LRRC32, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In