Transcriptional enhancer factor TEF-4

BE0014575ProteinHumansTEAD2

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. It is acted on by 1 drug in DrugBank.

Gene name
TEAD2
UniProtKB entry
Q15562Swiss-Prot
Cellular location
Nucleus
Residues / weight
447 residues · 49,242 Da
Also known as
TEA domain family member 2 · TEAD-2 · TEF4

Resolves to

Protein
UniProtQ15562UniProt nameTEAD2_HUMAN
Gene
HGNCHGNC:11715NCBI Gene8463GeneCardsTEAD2
Pharmacology
IUPHAR/GtoPdb3241KEGGhsa:8463
Structure
PDB3L15PDB5DQ8PDB5DQE
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Transcriptional enhancer factor TEF-4, and which indications are they being tested in?

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