G protein-coupled receptor 68

BE0014724ProteinHumansGPR68

Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed:33478938, PubMed:39753132, PubMed:40215959, PubMed:40215960). It is acted on by 1 drug in DrugBank.

Gene name
GPR68
UniProtKB entry
Q15743Swiss-Prot
Cellular location
Cell membrane
Residues / weight
365 residues · 41,076 Da
Also known as
G protein-coupled receptor 12A · GPR12A · OGR-1 · OGR1 · Ovarian cancer G protein-coupled receptor 1

Resolves to

Protein
UniProtQ15743UniProt nameGPR68_HUMAN
Gene
HGNCHGNC:4519NCBI Gene8111GeneCardsGPR68
Pharmacology
IUPHAR/GtoPdb114KEGGhsa:8111
Structure
PDB8Z3OPDB8Z5HPDB8Z68
Drugs

What you can answer from here — as of June 19, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on G protein-coupled receptor 68, and which indications are they being tested in?

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