Delta(24)-sterol reductase

BE0014791ProteinHumansDHCR24

Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:22178193, PubMed:25637936). It is acted on by 1 drug in DrugBank.

Gene name
DHCR24
UniProtKB entry
Q15392Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
516 residues · 60,101 Da
Also known as
1.3.1.72 · 24-dehydrocholesterol reductase · 3-beta-hydroxysterol Delta-24-reductase · Diminuto/dwarf1 homolog · KIAA0018

Resolves to

Protein
UniProtQ15392UniProt nameDHC24_HUMAN
Gene
HGNCHGNC:2859NCBI Gene1718GeneCardsDHCR24
Pharmacology
KEGGhsa:1718
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Delta(24)-sterol reductase, and which indications are they being tested in?

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